Protein Dynamics meets Photochemistry
Relay TX elaborates this unusual kinase inhibitor scaffold with a cross electrophile coupling in this one. make sure you check out...
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May 21, 2022
Cross electrophile - sans Ir
Here’s an interesting take on the reductive coupling thing. https://doi.org/10.1002/cssc.202200906 so… 4-CzIPN and Et3N instead of...
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May 21, 2022
Slick decarboxylation there Merck
This is another one from Merck. Those guys love them some Blue Light.
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May 21, 2022
How Bad is it?
Oh it's so bad, it's DBAD ! This one has two very different photoreactions. The first is a bit of a rarity: A cerium catalyzed...
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May 16, 2022
Boron's for Morons
Just kidding, this one has both a Molander boron XC and a MacMillan halide cross electrophile coupling.
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May 12, 2022
Another from Merck
Two blue light reactions in this one again from Merck. Both nice examples of late stage photochemical functionalization with either...
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May 12, 2022
Somebody make it enantioselective plz?
Today this one published from Merck. We know those guys love their blue light photoredox. Could one of you super smart types out there...
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May 11, 2022
Sensing a pattern here?
Another decarboxylative cross coupling seen here. BMS were early adopters.
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May 10, 2022
if only it were chiral...
Damn the free radicals, full speed ahead! This one is another fine example.
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May 10, 2022
Cyclopropanation - mild style
This one tells me that it looks like that Molander stuff works. and from the same application they use a pretty unusual decyanation
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May 10, 2022
Of course you can make BLU-5937 with a blue light!
This one is another nice example .of a reductive coupling. I believe 5937 is described as the methylcarbamate.
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May 9, 2022
Vertex has a SynLED
These are some cool as a cucumber compounds. I haven't used it, but Aldrich sells the "SynLED parallel Photoreactor". Currently...
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May 2, 2022
Look at that
Looks like some Nucleosides met up with a blue light. Good one BMS! I assume they separated the epimer.
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Apr 29, 2022
My Kinda MedChem
5% yield? Hey if it works figuring out how to scale it up is a good problem to have!
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Apr 29, 2022
Roche does it too.
They don't call out why in US/356967366 but they run it with a 420 nM light. Turns out the Kessil lamps can get you all the colors you...
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Apr 29, 2022
Another one seen in the wild
Here's another one with the Penn reactor: WO/2022/087634. This time 100 mg scale in 3 mL DMA! I bet you could run it more concentrated,...
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Apr 29, 2022
Sure takes a million reagents, Ey?
From WO/2022/084820: They use the Penn Photoreactor which is great. If my reaction volume was 1 mL that's probably what I'd use too!
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