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Aug 28, 2022
Davey Mac is in the house.
This one from everyone's favorite chemistry Nobel laureate is basically all photochemistry. If you like his stuff, you should check it...
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Aug 28, 2022
Protein Dynamics meets Photochemistry
Relay TX elaborates this unusual kinase inhibitor scaffold with a cross electrophile coupling in this one. make sure you check out...
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May 21, 2022
Cross electrophile - sans Ir
Here’s an interesting take on the reductive coupling thing. https://doi.org/10.1002/cssc.202200906 so… 4-CzIPN and Et3N instead of...
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May 16, 2022
Boron's for Morons
Just kidding, this one has both a Molander boron XC and a MacMillan halide cross electrophile coupling.
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May 12, 2022
Another from Merck
Two blue light reactions in this one again from Merck. Both nice examples of late stage photochemical functionalization with either...
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May 10, 2022
Of course you can make BLU-5937 with a blue light!
This one is another nice example .of a reductive coupling. I believe 5937 is described as the methylcarbamate.
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Apr 29, 2022
My Kinda MedChem
5% yield? Hey if it works figuring out how to scale it up is a good problem to have!
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Apr 29, 2022
Roche does it too.
They don't call out why in US/356967366 but they run it with a 420 nM light. Turns out the Kessil lamps can get you all the colors you...
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Apr 29, 2022
Sure takes a million reagents, Ey?
From WO/2022/084820: They use the Penn Photoreactor which is great. If my reaction volume was 1 mL that's probably what I'd use too!
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